Fludora Versus Actellic Insecticide: Fludora Proves to be more superior


Malaria vector control by indoor residual spraying (IRS) and the use of treated bed nets (insecticide-treated nets, ITNs and long-lasting insecticidal nets, LLINs) are the mainstay of vector control programs in malaria endemic countries such as Zambia. However, options for choosing insecticides for IRS campaigns and for treating bed nets are running out due to insecticide resistance which is threatening the efficacy of IRS and ITNs use in many countries including Zambia.
There is therefore urgent need for more innovative and effective alternative insecticides against resistant malaria vectors.
Scientists at TDRC have evaluated the efficacy of a new insecticide called FLUDORA, to establish its efficacy (and residual performance) when applied at recommended dose against lab reared susceptible An. gambiae, KISUMU strain compared to IRS Actellic 300CS (Pirimiphos-methyl 300g/L)‎
Fludora is a mixture of Clothianidin and Deltamethrin and introduces a new mode of action in IRS compounds never looked at before and has been reported to have promising results against multi insecticide resistant mosquitoes in the laboratory. It was compared with Actellic which the insecticide currently being used in the national malaria control programmes.
The study further conducted a phase II field trial in 40 randomly selected existing village huts in Nchelenge District an area with high burden of malaria despite several control efforts. The insecticide was tried on two types of plastered surfaces ( mud and cement respectively) and was evaluated for a period of nine months from September 2016 to June 2017.
The study revealed that efficacy on mud surfaces reduced much faster over time probably due to high rate of absorption of the sprayed insecticide.
At 6 months of evaluation the study revealed that the efficacy and residual activity of Fludora Fusion was far more superior compared to the benchmarking product, Actellic 300CS. On cement surfaces the 60 min knockdown on Fludora Fusion remained effective (above 95%) the entire 6 months while it remained effective for only 3 months on mud surfaces.
Therefore TDRC recommends that efficacy and residual activity exhibited by Fludora Fusion in this study is worth of the product inclusion in IRS national programs. Secondly it is highly recommended that cement plastering of houses be used in place of mud. However it is also recommended that for indoor residual spray programs implementing resistance management strategies and standard WHO susceptibility tests on the local vectors is conducted before adopting Fludora Fusion into the IRS programs.