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Tropical Diseases Research CentreTropical Diseases Research CentreTropical Diseases Research Centre
6th and 7th Floors, Ndola Central Hospital Building
Corner Nkana Road /Broadway

On-Going Projects

#Project Title and InvestigatorsObjective(s)Funder or Collaborating PartnersCostStart Date-End Date
1Effects of metronidazole plus intermittent preventive treatment of malaria in pregnancy on birth outcomes: a randomised controlled trial in Zambia (ASPIRE Study), PI-Dr. Mike Chaponda, CO-Investigators: Dr S. Hachizovu, Dr Michael Nambozi, Dr Enesia Chaponda-Ngulube, Prof Modest MulengaTo determine whether the combination of metronidazole (MTZ) with intermittent preventive treatment of malaria in pregnancy using sulphadoxine-pyrimethamine (IPTp-SP) or dihydroartemisinin-piperaquine (IPTp-DP) is superior to IPTp-SP alone in reducing adverse pregnancy outcomes related to malaria, bacterial vaginosis (BV), and Trichomonas vaginalis (TV) infections in pregnancy.Funder: Medical Research Council, UK, Sponsor: London School of Hygiene & Tropical Medicine£1,558,00017th Dec 2019 to 30th June 2023
2Measles and Rubella Vaccination Campaign Sero-survey in Select Districts in Zambia, PI: William Moss, Co Investigators: Kyla Hayford,   Simon Mutembo, Andrea Carcelen, Shaun Truelove, Gershom Chongwe,  Francis Mwansa, Phillimon Ndubani, Philip Thuma  To measure the proportion of children vaccinated at selected health care facilities during the measles and rubella SIA who are susceptible to measles and rubella, and the feasibility and acceptability of collecting dried blood spots (DBS) from children at the point of vaccination during an SIA.Bill and Melinda Gates Foundation through Johns Hopkins University  $87,000Sept 2020 – March 2021
3Flexible Serological Surveillance System in Zambia William Moss, Co Investigators:    Simon Mutembo,    Andrea Carcelen, Shaun Truelove, Gershom Chongwe, Francis Mwansa, Phillimon Ndubani, Philip ThumaTo assess the feasibility of using a Flexible Serological Surveillance System for Measles, Rubella and other pathogens in ZambiaBill and Melinda Gates Foundation through Johns Hopkins University$97,000March 2021-December 2022
4HIV and STI Biobehavioral Survey among High-Risk Men in selected Towns in Zambia  Maria Lahuerta, Lauren Parmley Leigh Tally, Brave Hanunka Jackson Okuku, Joyce Neal Gaston Djomand, Lazarous Chelu Chipili Mulemfwe, John Mwale,          Ray Handema,  Bwalya Innocent, Kapungu Kelvin, Kondowe ShepherdTo estimate the HIV care cascade, population size, prevalence of HIV, syphilis, hepatitis B (HBV) and hepatitis C (HCV), coinfections, sexual risk behaviours and access to preventive care for high risk men living with HIV.CDC through ICAP$433,000October 2020 –
5Zambia HIV Recent Infection Surveillance Lloyd Mulenga   Aaron Shibemba Gershom Chongwe Innocent BwalyaImplement a recent HIV infection surveillance system in Zambia, including integration of recent infection testing into routine HIV testing services; proportion and demographics of clients with a recent HIV infection.CDC,GRZ Nov 2019 –
6Routine data entry and management for COVID19 surveillance, Dr Gershom Chongwe, Dr Justin Chileshe, David Mwakazanga, Bridget M. Shanene, Lucy N. PhiriTo maintain an updated database of COVID19 test subjects and resultsMOH/TDRCRecurring cost2019-ongoing
7Using Household-centred Health Education and Routine Follow-up visits to improve utilization of  preventive and control measures of Malaria among household-leaders and school children in Nchelenge District, Kelvin Kapungu and Dr. Mike ChapondaTo determine the effectiveness of Household-centred Health Education and Routine Follow-up visits for improving utilization of preventive and control measures of Malaria among household-leaders and school children in Nchelenge District.ICEMR (Special Project)$15,000.00May 2019
8Pregnant women’s experiences and beliefs about Sexually Transmitted Infections in pregnancy and poor birth outcomes: A qualitative study to be conducted in Papua New Guinea (PNG) and Zambia, Dr. Chaponda and Kelvin KapunguTo understand the lived experiences and beliefs of pregnant women diagnosed with gonorrhoea, chlamydia, syphilis or trichomoniasis during pregnancy and had a preterm birth and or neonatal birthSNIS$20,300January
9Patient and Provider Attitudes to, and Interest in, Long Acting Formulations of Malaria Prophylaxis. Prof. Susan Swindells, Kelvin Kapungu, Dr. Gershom ChongweTo assess interest in and barriers associated with prescribing or receiving long-acting therapy to prevent malaria among individuals in areas with a high burden of malarial infection.WHO-(Unitaid), through University of Nebraska$50,000.00January to December 2021
 10International Centres of Excellence for Malaria Research (ICEMR) Project PI-Dr Mike Chaponda, Co PI Mr Mbanga MulebaOverall, the project aims to provide knowledge on malaria control from different transmission patterns in southern and central Africa. For TDRC, the study provides insight on why high transmission is sustained in Nchelenge district despite the various interventions employed by the ministry of health and its partners.National Institutes of Health (NIH) through JHU, Macha Research Trust, Biomedical Research and Training Institute, Harare, Zimbabwe, University of Witwatersrand, Universite Protestante au Congo, Kinshasa, DRC.$420,0001st April 2017 to 31st March 2024
11Safety and Efficacy of Intermittent Presumptive Treatment in pregnancy with Sulfadoxine-Pyrimethamine using Rapid Diagnostic Test Screening And Treatment at First Antenatal Care Visit, PI-Dr. Jean-Bertin Bukasa Kabuya, Co-Investigator Dr. Christine ManyandoTo evaluate the impact of adding, at first ANC, mRDT screening and treatment with DHA-PQ to the current IPTp-SP (IPTp-SP+) on IPT-SP efficacy at clearing maternal peripheral parasitemia and at preventing maternal anemia, LBW and neonatal mortality.European and Developing Countries Clinical Trial Partnership (EDCTP) through TDRC€ 149,999.3326/04/2019 to 30/06/2021
12Management of Malaria in African Countries: A multicenter, prospective, non-interventional study, PI: Dr S Hachizovu (Ipafu site), Co-Investigators: Dr Christine Manyando, Dr Jonathan GwasupikaTo describe the treatment prescribed (including adherence to WHO guidelines) to patients with a confirmed diagnosis of malaria, either uncomplicated or severe in real-life settings in AfricaNOVARTIS$37, 3751st Oct 2020, end date to be communicated
13Field study of the pharmacokinetics and pharmacodynamics of artemisinin-based combination therapy for gametocyte clearance in Zambian children with uncomplicated falciparum malaria (PHARCIDE), PI-Dr JB KabuyaTo model the pharmacokinetic and pharmacodynamic (PK/PD) profiles of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for gametocyte clearanceJohns Hopkins Bloomberg School of Public health with funding from the NIHFirst grant 2017/2:  $49,000, Subgrant/award 2019/10: $ 60,199,